Can't touch this, it's my new baby.
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More is always better
Starting the game
The Holy Trinity (very important early upgrades)
Basic Resource Rotation (strong basic infrastructure)
Further Resource Rotation (dual-resource structures)
The Four Rules
What you want
What you do
2nd reset goals
225 regular paragon = + 180% production, 150 regular + 75 burned= + 225% production
The three large components of storage cap are - Paragon, Horizons, and Space Buildings.
For paragon, you want a ton of short resets as fast as you can, for Horizons you kinda need either a long relic run (phase 2, so to say. phase 1 being relic stations, which you probably outgrew long ago), or a growing pile of B-coins (phase 3)
But paragon and cryptos are permanent.
So we optimize for storage buildings. And you, at this stage, refresh your unobt multiple times when you're capping chronospheres to your current unobt cap, so, we aren't trying to save unobtanium either (except maybe saving time)
Where we can do a significant difference, however, is antimatter. Both AI bases upgrade (7500) + ai cores to buff Moon bases to be equal or better than cryostations; And Sunforges to add an extra storage multiplier. Antimatter income is limited by unobt production, and shatter cooldown, so generally, in perfect conditions, you don't want to touch them at all.
And, since you're resetting with 70+ chronospheres, you're growing the resources you carry over. So, if you max out your antimatter cap, fill it, and reset with 71 chronospheres, you get free 6.5% antimatter. So, if you can get to the reset point by only spending, say, 0%-1% of your antimatter total, then you get 5%-6.5% PROFIT. Which, believe me, 20 resets later turns into at least +150% total.
Try to get 70+ chronospheres just by buildings and going to the Dark Future. Or, even better, without going to Dark Future at all, just by buildings. That saves you cooldown of 40 000 shatters, which is probably hours per run. You don't want to do runs for hours. You can get to year 40K in minutes if you spend a total of 9M TCs on boilers, furnaces, and shattering, but are you willing to do that? Questionable.
Eventually, you keep getting paragon, which makes it all easier and easier, and you also grow antimatter in stock, and then, at some point, you think - hey, I can spend, say... 10% of my massive growing antimatter pile, and that will let me get to 102+ chronospheres. Which is where the end-game starts.
And, same with other resources, all that you can. Void is slow, but if you save up the whole week long run's worth of void and then keep resetting over and over at +5% every time, it means that you get about 9 hours of void per reset, and snowballing with every reset. If you max out your compendiums/data centers/whatever, and then only spend 1% of your science on space stations, that means that several resets later your 1% science is gonna become several times larger.and you just keep stockpiling, until you maybe hit a breaking point to breach into end-game and then keep stockpiling again, but this time with unobtainium growing, too.
You can make do with 99 spheres I believe, the cutoff I think is just under 9G unobtainium storage. Once you reach that and reset with 99 or 100 spheres, you'll want to calculate the optimum number of spheres for maximum UO gains. If I remember correctly, a starting point of 100 spheres means that the optimal number for your next few resets will be around 73, but obviously that will increase as your stockpile increases. A spreadsheet will be the easiest way to calculate it simply, so you just type in your UO amount and it will tell you how many spheres to build
Regarding the rising blueprint costs, it's best early on to use mints, resource retrieval and shattering some time crystals to get them from furs. You will need to make sure you have geodesy along with geologists, farmers and a priest for solar revolution so that your gold and catnip doesn't get depleted. Later on, when you are able to reset with more spheres, sending huge numbers of trade caravans will be a far quicker method of getting blueprints, but it does mean that your catpower, gold and whatever trade material you are using will decrease relative to everything else. If you're resetting with enough spheres you should still see massive growth in those resources
Time crystals are a little more tricky because I believe they changed the way trading with the elders works. You used to be able to trade the elders for time crystals (and blueprints) without any energy, but it seems now that you need at least 1 fed necrocorn before you can get TCs from them. That means you'll likely have to do a long TC run to get them into the hundreds of millions, or possibly billions, and do quite a few resets with relatively fewer spheres until they run low. At that point, you likely have vastly inflated your stores of unobtainium, gold and catpower stockpiles, so a short TC run with a huge single trade should get you a stupid number of TCs, enough to last you for a loooooooong time. After that, rinse and repeat as you burn through the TCs and trade for exponentially growing amounts.
Also, there is a limit to this explosion. The game stores all resource values as floats, which have a definitive limit at around 1.797e308 (= 179.blahblah...QWWT). Going over that by resetting with too many spheres won't break your game, but it will revert that resource back down to 0. Generally speaking, once you reach that limit, the game is basically 'complete'. You can do resets with tens of thousands of kittens in order to get any remaining sephirots and inflate your storage, you can take your solar revolution bonus from the thousands to the millions, and you can get thousands of each of the cryptotheology buildings. What you do at that point is up to you, you can stop because you've essentially finished everything, you can clean up any remaining challenges or achievements, you can try and max out your CT structures with careful resets just under the JS limits, or you can just try and break the game. A couple of us have been simply trying to get every number in the game as high as possible, including things like temporal flux, most unicorns sacrificed, apocrypha bonus, etc. There are things to do, just nothing that really aligns with the rest of the game